1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Hippo (MST)
  4. Hippo (MST) Antagonist

Hippo (MST) Antagonist

Hippo (MST) Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-W1005067
    EN171
    Antagonist
    EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol.